About Dementia
Alzheimer's Disease

Amyloid Hypothesis

In Alzheimer's disease , brain cells responsible for processing, storing and receiving information become damaged and die. Beta-amyloid is suspected to play a part in this destruction. The "amyloid hypothesis" states that problems with increased levels of beta-amyloid cause Alzheimer's disease. Special molecules called proteins cut a large protein called Amyloid Precursor Protein (APP ) into smaller sections, one of these being beta-amyloid. Beta-amyloid is stickier than other fragments causing it to clump together into amyloid plaques. These plaques disrupt neurons by interfering with communication between them, and the cells eventually die.

top
Learn Track Join About Us Contact Information Dementia Community Site Map
Last updated August 30, 2007
©2006 DementiaGuide Inc.
Terms of Use Your Privacy